A Modeling Framework for Deriving the Structural and Functional Architecture of a Short-Term Memory Microcircuit
Author(s): Fisher, Dimitry; Olasagasti, Itsaso; Tank, David; Aksay, Emre; Goldman, Mark
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Fisher, Dimitry | - |
dc.contributor.author | Olasagasti, Itsaso | - |
dc.contributor.author | Tank, David | - |
dc.contributor.author | Aksay, Emre | - |
dc.contributor.author | Goldman, Mark | - |
dc.date.accessioned | 2023-12-12T15:07:06Z | - |
dc.date.available | 2023-12-12T15:07:06Z | - |
dc.date.issued | 2013-09-04 | en_US |
dc.identifier.citation | Fisher, Dimitry, Olasagasti, Itsaso, Tank, David W, Aksay, Emre RF, Goldman, Mark S. (2013). A Modeling Framework for Deriving the Structural and Functional Architecture of a Short-Term Memory Microcircuit. Neuron, 79 (5), 987 - 1000. doi:10.1016/j.neuron.2013.06.041 | en_US |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr1pg1hn7v | - |
dc.description.abstract | Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typical studies that construct a phenomenological model and test whether it reproduces select aspects of neuronal data, we directly fit the synaptic connectivity of an oculomotor memory circuit to a broad range of anatomical, electrophysiological, and behavioral data. Simultaneous fits to all data, combined with sensitivity analyses, revealed complementary roles of synaptic and neuronal-recruitment thresholds in providing the nonlinear interactions required to generate the observed circuit behavior. This work introduces a new methodology for identifying the cellular and synaptic mechanisms underlying short-term memory, and demonstrates how the anatomical structure of a circuit may belie its functional organization. | en_US |
dc.format.extent | 987 - 1000 | en_US |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Neuron | en_US |
dc.rights | Author's manuscript | en_US |
dc.title | A Modeling Framework for Deriving the Structural and Functional Architecture of a Short-Term Memory Microcircuit | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.1016/j.neuron.2013.06.041 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
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A_modeling_framework_memory_microcircut.pdf | 2.65 MB | Adobe PDF | View/Download |
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