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Synergistic catalysis: A powerful synthetic strategy for new reaction development

Author(s): Allen, Anna E.; MacMillan, David W.C.

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Abstract: ynergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.
Publication Date: 2012
Citation: Allen, Anna E., MacMillan, David W.C. (2012). Synergistic catalysis: A powerful synthetic strategy for new reaction development. Chemical Science, 3 (3), 633 - 633. doi:10.1039/c2sc00907b
DOI: doi:10.1039/c2sc00907b
ISSN: 2041-6520
EISSN: 2041-6539
Pages: 3, 633 - 633
Type of Material: Journal Article
Journal/Proceeding Title: Chemical Science
Version: Final published version. This is an open access article.
Notes: First published on 25th January 2012.

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