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|Abstract:||The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size–dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP) granules and other intracellular bodies. Many of these structures behave as condensed liquid-like phases of the cytoplasm/nucleoplasm. The phase transitions that appear to govern their assembly exhibit an intrinsic dependence on cell size, and may explain the size scaling reported for a number of structures. This size scaling could, in turn, play a role in cell growth and size control.|
|Citation:||Brangwynne, CP. (2013). Phase transitions and size scaling of membrane-less organelles. Journal of Cell Biology, 203 (875 - 881. doi:10.1083/jcb.201308087|
|Pages:||875 - 881|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Journal of Cell Biology|
|Version:||Final published version. This is an open access article.|
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