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A high-stringency blueprint of the human proteome

Author(s): Adhikari, Subash; Nice, Edouard C; Deutsch, Eric W; Lane, Lydie; Omenn, Gilbert S; et al

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Abstract: The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
Publication Date: 16-Oct-2020
Citation: Adhikari, Subash, Nice, Edouard C, Deutsch, Eric W, Lane, Lydie, Omenn, Gilbert S, Pennington, Stephen R, Paik, Young-Ki, Overall, Christopher M, Corrales, Fernando J, Cristea, Ileana M, Van Eyk, Jennifer E, Uhlén, Mathias, Lindskog, Cecilia, Chan, Daniel W, Bairoch, Amos, Waddington, James C, Justice, Joshua L, LaBaer, Joshua, Rodriguez, Henry, He, Fuchu, Kostrzewa, Markus, Ping, Peipei, Gundry, Rebekah L, Stewart, Peter, Srivastava, Sanjeeva, Srivastava, Sudhir, Nogueira, Fabio CS, Domont, Gilberto B, Vandenbrouck, Yves, Lam, Maggie PY, Wennersten, Sara, Vizcaino, Juan Antonio, Wilkins, Marc, Schwenk, Jochen M, Lundberg, Emma, Bandeira, Nuno, Marko-Varga, Gyorgy, Weintraub, Susan T, Pineau, Charles, Kusebauch, Ulrike, Moritz, Robert L, Ahn, Seong Beom, Palmblad, Magnus, Snyder, Michael P, Aebersold, Ruedi, Baker, Mark S. (2020). A high-stringency blueprint of the human proteome.. Nature communications, 11 (1), 5301 - ?. doi:10.1038/s41467-020-19045-9
DOI: doi:10.1038/s41467-020-19045-9
ISSN: 2041-1723
EISSN: 2041-1723
Pages: 5301 - 5301
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Nature Communications
Version: Final published version. This is an open access article.

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