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DNA-binding-protein inhomogeneity in coli modeled as biphasic facilitated diffusion

Author(s): Kuhlman, Thomas E; Cox, Edward C

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Abstract: We have recently shown that nonspecifically bound lac repressors are spatially inhomogeneous in E. coli cells and depends upon the location of its encoding gene and the DNA compaction state [Kuhlman and Cox, Mol. Syst. Biol. 8, 610 (2012)]. Here we model this inhomogeneity as a consequence of diffusion within and exchange between two distinct intracellular phases: the condensed chromosomal DNA and an extrachromosomal compartment, the cytoplasm. We discuss the consequences of this model for the target search process.
Publication Date: Aug-2013
Electronic Publication Date: 1-Aug-2013
Citation: Kuhlman, Thomas E, Cox, Edward C. (2013). DNA-binding-protein inhomogeneity in coli modeled as biphasic facilitated diffusion. Physical Review E, 88 (2), 10.1103/PhysRevE.88.022701
DOI: doi:10.1103/PhysRevE.88.022701
ISSN: 1539-3755
EISSN: 1550-2376
Pages: 1 - 6
Type of Material: Journal Article
Journal/Proceeding Title: Physical Review E
Version: Final published version. This is an open access article.

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