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Role of mother's genes and environment in postpartum depression

Author(s): Mitchell, Colter; Notterman, Daniel A.; Brooks-Gunn, Jeanne; Hobcraft, John; Garfinkel, Irwin; et al

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Abstract: Most studies of human molecular genetics and social environment interactions on health have relied heavily on the classic diathesis-stress model that treats genetic variations and environments as being either “risky” or “protective.” The biological susceptibility model posits that some individuals have greater genetic reactivity to stress, leading to worse outcomes in poor environments, but better outcomes in rich environments. Using a nontruncated measure of a chronic environmental stressor—socioeconomic status— measured by education, and two polymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter gene (5-HTT), we find strong evidence that some women are genetically more reactive to the environment, resulting in a crossover of risks of postpartum depression for the most reactive groups. We discuss how our approach and findings provide a framework for understanding some of the confusion in the gene-environment interaction literature on stress, 5-HTT, and depression.
Publication Date: 17-May-2011
Electronic Publication Date: 16-May-2011
Citation: Mitchell, C., Notterman, D., Brooks-Gunn, J., Hobcraft, J., Garfinkel, I., Jaeger, K., Kotenko, I., McLanahan, S. (2011). Role of mother's genes and environment in postpartum depression. Proceedings of the National Academy of Sciences, 108 (20), 8189 - 8193. doi:10.1073/pnas.1014129108
DOI: doi:10.1073/pnas.1014129108
ISSN: 0027-8424
EISSN: 1091-6490
Pages: 8189 - 8193
Type of Material: Journal Article
Journal/Proceeding Title: Proceedings of the National Academy of Sciences
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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