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β-Spectrin Regulates the Hippo Signaling Pathway and Modulates the Basal Actin Network

Author(s): Wong, Kenneth Kin Lam; Li, Wenyang; An, Yanru; Duan, Yangyang; Li, Zhuoheng; et al

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Abstract: Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for -Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. -Spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A similar reduction of Hippo signaling activity was observed after -Spectrin knockdown in mammalian cells. We further demonstrated that -spectrin mutations disrupt the basal actin network in follicle cells. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the -spectrin mutations and the loss of the Hippo signaling activity phenotype.
Publication Date: 6-Mar-2015
Electronic Publication Date: 14-Jan-2015
Citation: Wong, Kenneth Kin Lam, Li, Wenyang, An, Yanru, Duan, Yangyang, Li, Zhuoheng, Kang, Yibin, Yan, Yan. (2015). β-Spectrin Regulates the Hippo Signaling Pathway and Modulates the Basal Actin Network. Journal of Biological Chemistry, 290 (10), 6397 - 6407. doi:10.1074/jbc.M114.629493
DOI: doi:10.1074/jbc.M114.629493
ISSN: 0021-9258
EISSN: 1083-351X
Pages: 6397 - 6407
Type of Material: Journal Article
Journal/Proceeding Title: Journal of Biological Chemistry
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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