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Extended pulsated drug release from PLGA-based minirods

Author(s): Danyuo, Y; E. Oberaifo, O; Obayemi, JD; Dozie-Nwachukwu, S; J. Ani, C; et al

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Abstract: The kinetics of degradation and sustained cancer drugs (paclitaxel (PT) and prodigiosin (PG)) release are presented for minirods (each with diameter of ~5 and ~6 mm thick). Drug release and degradation mechanisms were studied from solvent-casted cancer drug-based minirods under in vitro conditions in phosphate buffer solution (PBS) at a pH of 7.4. The immersed minirods were mechanically agitated at 60 revolutions per minute (rpm) under incubation at 37 °C throughout the period of the study. The kinetics of drug release was studied using ultraviolet visible spectrometry (UV-Vis). This was used to determine the amount of drug released at 535 nm for poly(lactic-co-glycolic acid) loaded with prodigiosin (PLGA-PG) samples, and at 210 nm, for paclitaxel-loaded samples (PLGA-PT). The degradation characteristics of PLGA-PG and PLGA-PT are elucidated using optical microscope as well as scanning electron microscope (SEM). Statistical analysis of drug release and degradation mechanisms of PLGA-based minirods were performed. The implications of the results are discussed for potential applications in implantable/degradable structures for multi-pulse cancer drug delivery.
Publication Date: 1-Mar-2017
Citation: Danyuo, Yiporo, O. E. Oberaifo, J. D. Obayemi, S. Dozie-Nwachukwu, C. J. Ani, O. S. Odusanya, MG Zebaze Kana, K. Malatesta, and W. O. Soboyejo. "Extended pulsated drug release from PLGA-based minirods." Journal of Materials Science: Materials in Medicine 28, no. 61 (2017): 1-10. doi: 10.1007/s10856-017-5866-y
DOI: doi:10.1007/s10856-017-5866-y
ISSN: 0957-4530
EISSN: 1573-4838
Pages: 1 - 10
Type of Material: Journal Article
Journal/Proceeding Title: Journal of Materials Science: Materials in Medicine
Version: Author's manuscript

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