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Polymeric composite devices for localized treatment of early-stage breast cancer

Author(s): Kan-Dapaah, Kwabena; Rahbar, Nima; Soboyejo, Wole

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Abstract: For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20–55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment.
Publication Date: 28-Feb-2017
Citation: Kan-Dapaah, Kwabena, Nima Rahbar, and Wole Soboyejo. "Polymeric composite devices for localized treatment of early-stage breast cancer." PloS ONE 12, no. 2 (2017): e0172542. doi: 10.1371/journal.pone.0172542
DOI: doi:10.1371/journal.pone.0172542
EISSN: 1932-6203
Pages: e0172542
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: PloS ONE
Version: Final published version. This is an open access article.

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