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Determinants of hepatitis B and delta virus host tropism

Author(s): Winer, Benjamin Y; Ploss, Alexander

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Abstract: Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15–20 million are co-infected with hepatitis delta virus (HDV). Progress towards curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid the construction of a small animal model with inheritable susceptible to HBV/ HDV.
Publication Date: Aug-2015
Electronic Publication Date: 8-Jul-2015
Citation: Winer, Benjamin Y, Ploss, Alexander. (2015). Determinants of hepatitis B and delta virus host tropism. Current Opinion in Virology, 13 (109 - 116. doi:10.1016/j.coviro.2015.06.004
DOI: doi:10.1016/j.coviro.2015.06.004
ISSN: 1879-6257
Pages: 109 - 116
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Virology
Version: Author's manuscript

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