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Computational models of airway branching morphogenesis

Author(s): Varner, Victor D.; Nelson, Celeste M.

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Abstract: The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches – geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling – and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis.
Publication Date: Jul-2017
Electronic Publication Date: 2017
Citation: Varner, Victor D, Nelson, Celeste M. (2017). Computational models of airway branching morphogenesis. Seminars in Cell & Developmental Biology, 67 (170 - 176). doi:10.1016/j.semcdb.2016.06.003
DOI: doi:10.1016/j.semcdb.2016.06.003
ISSN: 1084-9521
Pages: 170 - 176
Type of Material: Journal Article
Journal/Proceeding Title: Seminars in Cell & Developmental Biology
Version: Author's manuscript

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