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Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

Author(s): Perez, Lark J; Karagounis, Theodora K; Hurley, Amanda; Bassler, Bonnie L.; Semmelhack, Martin F

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Abstract: In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.
Publication Date: 2014
Electronic Publication Date: 2014
Citation: Perez, Lark J, Karagounis, Theodora K, Hurley, Amanda, Bassler, Bonnie L, Semmelhack, Martin F. (2014). Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae. Chem. Sci., 5 (1), 151 - 155. doi:10.1039/C3SC52572D
DOI: doi:10.1039/C3SC52572D
ISSN: 2041-6520
EISSN: 2041-6539
Related Item: DOI: 10.1039/c3sc52572d
Pages: 151 - 155
Type of Material: Journal Article
Journal/Proceeding Title: Chem. Sci.
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.
Notes: Electronic supplementary information (ESI) available: Experimental procedures, structural proofs, and spectral data for all new compounds are provided. See DOI in related item field.

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