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Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

Author(s): Perez, Lark J; Karagounis, Theodora K; Hurley, Amanda; Bassler, Bonnie L.; Semmelhack, Martin F

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dc.contributor.authorPerez, Lark J-
dc.contributor.authorKaragounis, Theodora K-
dc.contributor.authorHurley, Amanda-
dc.contributor.authorBassler, Bonnie L.-
dc.contributor.authorSemmelhack, Martin F-
dc.date.accessioned2022-01-14T17:04:04Z-
dc.date.available2022-01-14T17:04:04Z-
dc.date.issued2014en_US
dc.identifier.citationPerez, Lark J, Karagounis, Theodora K, Hurley, Amanda, Bassler, Bonnie L, Semmelhack, Martin F. (2014). Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae. Chem. Sci., 5 (1), 151 - 155. doi:10.1039/C3SC52572Den_US
dc.identifier.issn2041-6520-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr17w1d-
dc.descriptionElectronic supplementary information (ESI) available: Experimental procedures, structural proofs, and spectral data for all new compounds are provided. See DOI in related item field.en_US
dc.description.abstractIn the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.en_US
dc.format.extent151 - 155en_US
dc.relationDOI: 10.1039/c3sc52572den_US
dc.relation.ispartofChem. Sci.en_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleHighly potent, chemically stable quorum sensing agonists for vibrio Choleraeen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1039/C3SC52572D-
dc.date.eissued2014en_US
dc.identifier.eissn2041-6539-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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