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Implantable polymer/metal thin film structures for the localized treatment of cancer by Joule heating

Author(s): Kan-Dapaah, K; Rahbar, N; Theriault, C; Soboyejo, W

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Abstract: This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The predictions are also compared to prior results from in vitro studies and relevant in vivo studies in the literature. The implications of the results are discussed for the potential application of polymer/metal thin film structures in hyperthermic treatment of cancer.
Publication Date: 2015
Citation: Kan-Dapaah, Kwabena, Nima Rahbar, Christian Theriault, and Wole Soboyejo. "Implantable polymer/metal thin film structures for the localized treatment of cancer by Joule heating." Journal of Applied Physics 117, no. 16 (2015): 165301. doi: 10.1063/1.4918271
DOI: doi:10.1063/1.4918271
ISSN: 0021-8979
EISSN: 1089-7550
Pages: 165301
Type of Material: Journal Article
Journal/Proceeding Title: Journal of Applied Physics
Version: Author's manuscript

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