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Hierarchical Size Scaling during Multicellular Growth and Development

Author(s): Uppaluri, Sravanti; Weber, Stephanie C.; Brangwynne, Clifford P.

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Abstract: Multicellular organisms must regulate their growth across the diverse length scales of biological organization, but how this growth is controlled from organelle to body, while coordinating interdependent functions at each scale, remains poorly understood. We utilized the C. elegans worm intestine as a model system to identify distinct allometric scaling laws, revealing that the growth of individual structures is differentially regulated during development. We show that the volume of the nucleolus, a subcellular organelle, is directly proportional (isometric) to cell size during larval development. In contrast to findings in a variety of other systems, the size of the nucleus grows more slowly and is hypoallometric to the cell. We further demonstrate that the relative size of the nucleolus, the site of ribosome biogenesis, is predictive of the growth rate of the entire worm. These results highlight the importance of subcellular size for organism-level function in multicellular organisms.
Publication Date: 4-Oct-2016
Electronic Publication Date: 2016
Citation: Uppaluri, S, Weber, SC, Brangwynne, CP. (2016). Hierarchical Size Scaling during Multicellular Growth and Development. Cell Reports, 17 (345 - 352). doi:10.1016/j.celrep.2016.09.007
DOI: doi:10.1016/j.celrep.2016.09.007
Pages: 345 - 352
Type of Material: Journal Article
Journal/Proceeding Title: Cell Reports
Version: Final published version. This is an open access article.

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