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Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

Author(s): Gibney, Patrick A; Schieler, Ariel; Chen, Jonathan C; Bacha-Hummel, Jessie M; Botstein, Maxim; et al

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dc.contributor.authorGibney, Patrick Aen_US
dc.contributor.authorSchieler, Arielen_US
dc.contributor.authorChen, Jonathan Cen_US
dc.contributor.authorBacha-Hummel, Jessie Men_US
dc.contributor.authorBotstein, Maximen_US
dc.contributor.authorVolpe, Matthewen_US
dc.contributor.authorSilverman, Sanford Jen_US
dc.contributor.authorXu, Yifanen_US
dc.contributor.authorBennett, Bryson Den_US
dc.contributor.authorRabinowitz, Joshua Den_US
dc.contributor.authorBotstein, Daviden_US
dc.date.accessioned2020-02-29T03:39:04Z-
dc.date.available2020-02-29T03:39:04Z-
dc.date.issued2018-04en_US
dc.identifier.citationGibney, Patrick A, Schieler, Ariel, Chen, Jonathan C, Bacha-Hummel, Jessie M, Botstein, Maxim, Volpe, Matthew, Silverman, Sanford J, Xu, Yifan, Bennett, Bryson D, Rabinowitz, Joshua D, Botstein, David. (2018). Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.. Molecular biology of the cell, 29 (8), 897 - 910. doi:10.1091/mbc.E17-11-0666en_US
dc.identifier.issn1059-1524en_US
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr16v23-
dc.description.abstractMetabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.en_US
dc.format.extent897 - 910en_US
dc.languageengen_US
dc.relation.ispartofMolecular biology of the cellen_US
dc.titleCommon and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.en_US
dc.typeJournal Article-
dc.identifier.doidoi:10.1091/mbc.E17-11-0666en_US
dc.identifier.eissn1939-4586en_US
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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