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 Abstract: OBJECTIVE: Unintended pregnancies (UP) are associated with a significant cost burden but the full cost burden in Canada is not known. The objectives were to quantify the direct cost of UPs in Canada, the proportion of UPs and cost attributable to imperfect contraceptive adherence, and the potential cost-savings with increased uptake of long-acting reversible contraceptives (LARCs). METHODS: A cost model was constructed to estimate the annual number and direct costs of UP in women aged 18–44 years. Adherence-associated UP rates were estimated using perfect- and typical-use contraceptive failure rates. Change in annual number of UPs and impact on cost-burden were projected in 3 scenarios of increased LARC usage. One-way sensitivity analyses were conducted to assess the impact of key variables on scenarios of increased LARC use. RESULTS: There are over 180,700 UPs annually in Canada. The associated direct cost was over $320 million. Fifty-eight percent (58%) of UPs occurred in women aged 20–29 years at an annual cost of$175 million; 82% of this cost ($143 million) was attributable to contraceptive non-adherence. Increased LARC uptake produced cost savings of over$34 million in all three switching scenarios; the largest savings (\$35 million) occurred when 10% of oral contraceptive users switched to LARCs. The minimum duration of LARC usage required before cost savings was realized was 12 months. CONCLUSIONS: The cost of UPs in Canada is significant and much of it can be attributed to imperfect contraceptive adherence. Increased LARC uptake may reduce contraceptive non-adherence thereby reducing rates of UP and generating significant cost savings, particularly in women aged 20–29. Publication Date: 2015 Citation: Black, AY, Guilbert, E, Hassan, F, Chatziheofilou, I, Lowin, J, Jeddi, M, Filonenko, A, Trussell, J. (2015). The Cost of Unintended Pregnancies (CoUP) in Canada: Estimating Direct Cost, Role of Imperfect Adherence, and the Potential Impact of Increased Use of Long-Acting Reversible Contraceptives. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 37 (1086 - 1097) ISSN: 1701-2163 Pages: 1086 - 1097 Type of Material: Journal Article Journal/Proceeding Title: Journal of Obstetrics and Gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC Version: Author's manuscript