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Know the Single-Receptor Sensing Limit? Think Again

Author(s): Aquino, Gerardo; Wingreen, Ned; Endres, Robert G

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Abstract: How cells reliably infer information about their environment is a fundamentally important question. While sensing and signaling generally start with cell-surface receptors, the degree of accuracy with which a cell can measure external ligand concentration with even the simplest device - a single receptor - is surprisingly hard to pin down. Recent studies provide conflicting results for the fundamental physical limits. Comparison is made difficult as different studies either suggest different readout mechanisms of the ligand-receptor occupancy, or differ on how ligand diffusion is implemented. Here we critically analyse these studies and present a unifying perspective on the limits of sensing, with wide-ranging biological implications.
Publication Date: Mar-2016
Electronic Publication Date: 23-Nov-2015
Citation: Aquino, Gerardo, Wingreen, Ned S, Endres, Robert G. (2016). Know the Single-Receptor Sensing Limit? Think Again. Journal of Statistical Physics, 162 (5), 1353 - 1364. doi:10.1007/s10955-015-1412-9
DOI: doi:10.1007/s10955-015-1412-9
ISSN: 0022-4715
EISSN: 1572-9613
Pages: 1353 - 1364
Type of Material: Journal Article
Journal/Proceeding Title: Journal of Statistical Physics
Version: Author's manuscript

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