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Quantitative approaches to uncover physical mechanisms of tissue morphogenesis

Author(s): Gleghorn, Jason P; Manivannan, Sriram; Nelson, Celeste M

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Abstract: Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.
Publication Date: Oct-2013
Electronic Publication Date: 2013
Citation: Gleghorn, Jason P, Manivannan, Sriram, Nelson, Celeste M. (2013). Quantitative approaches to uncover physical mechanisms of tissue morphogenesis. Current Opinion in Biotechnology, 24 (5), 954 - 961. doi:10.1016/j.copbio.2013.04.006
DOI: doi:10.1016/j.copbio.2013.04.006
ISSN: 0958-1669
Pages: 954 - 961
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Biotechnology
Version: Author's manuscript

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