Skip to main content

Genomes and Virulence Factors of Novel Bacterial Pathogens Causing Bleaching Disease in the Marine Red Alga Delisea pulchra

Author(s): Fernandes, Neil; Case, Rebecca J.; Longford, Sharon R.; Seyedsayamdost, Mohammad R.; Steinberg, Peter D.; et al

To refer to this page use:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFernandes, Neil-
dc.contributor.authorCase, Rebecca J.-
dc.contributor.authorLongford, Sharon R.-
dc.contributor.authorSeyedsayamdost, Mohammad R.-
dc.contributor.authorSteinberg, Peter D.-
dc.contributor.authorKjelleberg, Staffan-
dc.contributor.authorThomas, Torsten-
dc.identifier.citationFernandes, Neil, Case, Rebecca J, Longford, Sharon R, Seyedsayamdost, Mohammad R, Steinberg, Peter D, Kjelleberg, Staffan, Thomas, Torsten. (2011). Genomes and Virulence Factors of Novel Bacterial Pathogens Causing Bleaching Disease in the Marine Red Alga Delisea pulchra. PLoS ONE, 6 (12), e27387 - e27387. doi:10.1371/journal.pone.0027387en_US
dc.description.abstractNautella sp. R11, a member of the marine Roseobacter clade, causes a bleaching disease in the temperate-marine red macroalga, Delisea pulchra. To begin to elucidate the molecular mechanisms underpinning the ability of Nautella sp. R11 to colonize, invade and induce bleaching of D. pulchra, we sequenced and analyzed its genome. The genome encodes several factors such as adhesion mechanisms, systems for the transport of algal metabolites, enzymes that confer resistance to oxidative stress, cytolysins, and global regulatory mechanisms that may allow for the switch of Nautella sp. R11 to a pathogenic lifestyle. Many virulence effectors common in phytopathogenic bacteria are also found in the R11 genome, such as the plant hormone indole acetic acid, cellulose fibrils, succinoglycan and nodulation protein L. Comparative genomics with non-pathogenic Roseobacter strains and a newly identified pathogen, Phaeobacter sp. LSS9, revealed a patchy distribution of putative virulence factors in all genomes, but also led to the identification of a quorum sensing (QS) dependent transcriptional regulator that was unique to pathogenic Roseobacter strains. This observation supports the model that a combination of virulence factors and QS-dependent regulatory mechanisms enables indigenous members of the host alga's epiphytic microbial community to switch to a pathogenic lifestyle, especially under environmental conditions when innate host defence mechanisms are compromised.en_US
dc.format.extente27387-1 - e27387-12en_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleGenomes and Virulence Factors of Novel Bacterial Pathogens Causing Bleaching Disease in the Marine Red Alga Delisea pulchraen_US
dc.typeJournal Articleen_US

Files in This Item:
File Description SizeFormat 
journal.pone.0027387.PDF380.11 kBAdobe PDFView/Download
journal.pone.0027387.t001.png197.38 kBimage/pngThumbnail
journal.pone.0027387.g001.png2.04 MBimage/pngThumbnail
journal.pone.0027387.t002.png33.4 kBimage/pngThumbnail
journal.pone.0027387.t003.png14.48 kBimage/pngThumbnail
journal.pone.0027387.g002.png55.28 kBimage/pngThumbnail
journal.pone.0027387.t003 (1).png97.06 kBimage/pngThumbnail
journal.pone.0027387.g002 (1).png365.87 kBimage/pngThumbnail
journal.pone.0027387.g003.png721.95 kBimage/pngThumbnail
journal.pone.0027387.t005.png29.28 kBimage/pngThumbnail

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.