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Definitions and guidelines for research on antibiotic persistence.

Author(s): Balaban, Nathalie Q; Helaine, Sophie; Lewis, Kim; Ackermann, Martin; Aldridge, Bree; et al

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Abstract: Increasing concerns about the rising rates of antibiotic therapy failure and advances in┬ásingle-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
Publication Date: Jul-2019
Electronic Publication Date: 12-Apr-2019
Citation: Balaban, Nathalie Q, Helaine, Sophie, Lewis, Kim, Ackermann, Martin, Aldridge, Bree, Andersson, Dan I, Brynildsen, Mark P, Bumann, Dirk, Camilli, Andrew, Collins, James J, Dehio, Christoph, Fortune, Sarah, Ghigo, Jean-Marc, Hardt, Wolf-Dietrich, Harms, Alexander, Heinemann, Matthias, Hung, Deborah T, Jenal, Urs, Levin, Bruce R, Michiels, Jan, Storz, Gisela, Tan, Man-Wah, Tenson, Tanel, Van Melderen, Laurence, Zinkernagel, Annelies. (2019). Definitions and guidelines for research on antibiotic persistence.. Nature reviews. Microbiology, 17 (7), 441 - 448. doi:10.1038/s41579-019-0196-3
DOI: doi:10.1038/s41579-019-0196-3
ISSN: 1740-1526
EISSN: 1740-1534
Pages: 441 - 448
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Nature reviews. Microbiology
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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