Skip to main content

Sequence dependence of biomolecular phase separation

Author(s): Weiner, Benjamin; Meir, Yigal; Wingreen, Ned

To refer to this page use:
Abstract: Cells are home to a host of biomolecular condensates – phase-separated droplets that lack a membrane. In addition to nonspecific interactions, phase separation depends on specific binding motifs between constituent molecules. Nevertheless, few rules have been established on how these specific, heterotypic interactions drive phase separation. Using lattice-polymer simulations and mean-field theory, we find that the sequence of binding motifs strongly affects a polymer’s ability to phase separate, influencing both phase boundaries and condensate properties (e.g. viscosity). Notably, sequence primarily acts by determining the conformational entropy of self-bonding by single polymers.
Publication Date: 25-Sep-2020
Citation: Weiner, Benjamin, Meir, Yigal, Wingreen, Ned. (2020). Sequence dependence of biomolecular phase separation. 10.1101/2020.09.24.312330
DOI: doi:10.1101/2020.09.24.312330
Pages: 2020-09-15
Type of Material: Journal Article
Journal/Proceeding Title: BioRxiv
Version: Author's manuscript

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.