Mouse genomic screen reveals novel host regulator of metastasis.
Author(s): Celià-Terrassa, Toni; Kang, Yibin
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http://arks.princeton.edu/ark:/88435/pr10z0b| Abstract: | Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization. |
| Publication Date: | 16-Feb-2017 |
| Citation: | Celià-Terrassa, Toni, Kang, Yibin. (2017). Mouse genomic screen reveals novel host regulator of metastasis.. Genome biology, 18 (1), 31 - ?. doi:10.1186/s13059-017-1170-x |
| DOI: | doi:10.1186/s13059-017-1170-x |
| ISSN: | 1474-7596 |
| EISSN: | 1474-760X |
| Pages: | 1 - 3 |
| Language: | eng |
| Type of Material: | Journal Article |
| Journal/Proceeding Title: | Genome biology |
| Version: | Final published version. Article is made available in OAR by the publisher's permission or policy. |
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