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|Abstract:||Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.|
|Citation:||Celià-Terrassa, Toni, Kang, Yibin. (2017). Mouse genomic screen reveals novel host regulator of metastasis.. Genome biology, 18 (1), 31 - ?. doi:10.1186/s13059-017-1170-x|
|Pages:||1 - 3|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Genome biology|
|Version:||Final published version. Article is made available in OAR by the publisher's permission or policy.|
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