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Mouse genomic screen reveals novel host regulator of metastasis.

Author(s): Celià-Terrassa, Toni; Kang, Yibin

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Abstract: Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.
Publication Date: 16-Feb-2017
Citation: Celià-Terrassa, Toni, Kang, Yibin. (2017). Mouse genomic screen reveals novel host regulator of metastasis.. Genome biology, 18 (1), 31 - ?. doi:10.1186/s13059-017-1170-x
DOI: doi:10.1186/s13059-017-1170-x
ISSN: 1474-7596
EISSN: 1474-760X
Pages: 1 - 3
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Genome biology
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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