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Outer Membrane Protein Insertion by the β-barrel Assembly Machine.

Author(s): Ricci, Dante P; Silhavy, Thomas J

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Abstract: Like all outer membrane (OM) constituents, integral OM β-barrel proteins in Gram-negative bacteria are synthesized in the cytoplasm and trafficked to the OM, where they are locally assembled into the growing OM by the ubiquitous β-barrel assembly machine (Bam). While the identities and structures of all essential and accessory Bam components have been determined, the basic mechanism of Bam-assisted OM protein integration remains elusive. Here we review mechanistic analyses of OM β-barrel protein folding and Bam dynamics and summarize recent insights that inform a general model for OM protein recognition and assembly by the Bam complex.
Publication Date: Mar-2019
Citation: Ricci, Dante P, Silhavy, Thomas J. (2019). Outer Membrane Protein Insertion by the β-barrel Assembly Machine. EcoSal Plus, 8 (2), 10.1128/ecosalplus.esp-0035-2018
DOI: doi:10.1128/ecosalplus.esp-0035-2018
ISSN: 2324-6200
EISSN: 2324-6200
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: EcoSal Plus
Version: Author's manuscript

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