Skip to main content

Interspecies activity correlations reveal functional correspondence between monkey and human brain areas

Author(s): Mantini, Dante; Hasson, Uri; Betti, Viviana; Perrucci, Mauro G.; Romani, Gian Luca; et al

To refer to this page use:
Abstract: Evolution-driven functional changes in the primate brain are typically assessed by aligning monkey and human activation maps using cortical surface expansion models. These models use putative homologous areas as registration landmarks, assuming they are functionally correspondent. In cases where functional changes have occurred in an area, this assumption prohibits to reveal whether other areas may have assumed lost functions. Here we describe a method to examine functional correspondences across species. Without making spatial assumptions, we assess similarities in sensory-driven functional magnetic resonance imaging responses between monkey (Macaca mulatta) and human brain areas by means of temporal correlation. Using natural vision data, we reveal regions for which functional processing has shifted to topologically divergent locations during evolution. We conclude that substantial evolution-driven functional reorganizations have occurred, not always consistent with cortical expansion processes. This novel framework for evaluating changes in functional architecture is crucial to building more accurate evolutionary models.
Publication Date: Mar-2012
Electronic Publication Date: 5-Feb-2012
Citation: Mantini, Dante, Hasson, Uri, Betti, Viviana, Perrucci, Mauro G, Romani, Gian Luca, Corbetta, Maurizio, Orban, Guy A, Vanduffel, Wim. (2012). Interspecies activity correlations reveal functional correspondence between monkey and human brain areas. Nature Methods, 9 (3), 277 - 282. doi:10.1038/nmeth.1868
DOI: doi:10.1038/nmeth.1868
ISSN: 1548-7091
EISSN: 1548-7105
Pages: 277 - 282
Type of Material: Journal Article
Journal/Proceeding Title: Nature Methods
Version: Author's manuscript

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.