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Mechanical frustration of phase separation in the cell nucleus by chromatin

Author(s): Zhang, Yaojun; Lee, Daniel SW; Meir, Yigal; Brangwynne, Clifford; Wingreen, Ned

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Abstract: Liquid-liquid phase separation is a fundamental mechanism underlying subcellular organization. Motivated by the striking observation that optogenetically-generated droplets in the nucleus display suppressed coarsening dynamics, we study the impact of chromatin mechanics on droplet phase separation. We combine theory and simulation to show that crosslinked chromatin can mechanically suppress droplets’ coalescence and ripening, as well as quantitatively control their number, size, and placement. Our results highlight the role of the subcellular mechanical environment on condensate regulation.
Publication Date: 24-Dec-2020
Citation: Zhang, Yaojun, Lee, Daniel SW, Meir, Yigal, Brangwynne, Clifford, Wingreen, Ned. (2020). Mechanical frustration of phase separation in the cell nucleus by chromatin. 10.1101/2020.12.24.424222
DOI: doi:10.1101/2020.12.24.424222
Type of Material: Journal Article
Journal/Proceeding Title: bioRxiv
Version: Author's manuscript

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