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A metagenomic strategy for harnessing the chemical repertoire of the human microbiome

Author(s): Sugimoto, Yuki; Camacho, Francine R.; Wang, Shuo; Chankhamjon, Pranatchareeya; Odabas, Arman; et al

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Abstract: Remarkable progress has been made in determining the effects of the microbiome on human physiology and disease, but the underlying molecules and mechanisms governing these effects remain largely unexplored. Here, we combine a new computational algorithm with synthetic biology to access biologically active small molecules encoded directly in human microbiome-derived metagenomic sequencing data. We discover that members of a clinically used class of molecules are widely encoded in the human microbiome, and that they exert potent antibacterial activities against neighboring microbes, implying a possible role in niche competition and host defense. Our approach paves the way toward a systematic unveiling of the chemical repertoire encoded by the human microbiome and provides a generalizable platform for discovering molecular mediators of microbiome-host and microbiome-microbiome interactions.
Publication Date: 2019
Citation: Sugimoto, Yuki, Camacho, Francine R, Wang, Shuo, Chankhamjon, Pranatchareeya, Odabas, Arman, Biswas, Abhishek, Jeffrey, Philip D, Abou Donia, Mohamed S. (2019). A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Science, eaax9176 - eaax9176
DOI: doi:10.1126/science.aax9176
Pages: 1 - 16
Type of Material: Journal Article
Journal/Proceeding Title: Science
Version: Author's manuscript

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