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Acute Infection Induces a Metastatic Niche: A Double Menace for Cancer Patients

Author(s): Smith, HA; Kang, Yibin

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Abstract: Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.
Publication Date: 6-Aug-2013
DOI: doi:10.1158/1078-0432.CCR-13-1524
ISSN: 1078-0432
EISSN: 1557-3265
Type of Material: Journal Article
Journal/Proceeding Title: Clinical Cancer Research
Version: Final published version. This is an open access article.

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