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Distinct Rap1 Activity States Control the Extent of Epithelial Invagination via α-Catenin

Author(s): Wang, Yu-Chiun; Khan, Zia; Wieschaus, Eric F

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Abstract: Localized cell shape change initiates epithelial folding, while neighboring cell invagination determines the final depth of an epithelial fold. The mechanism that controls the extent of invagination remains unknown. During Drosophila gastrulation, a higher number of cells undergo invagination to form the deep posterior dorsal fold, whereas far fewer cells become incorporated into the initially very similar anterior dorsal fold. We find that a decrease in α-Catenin activity causes the anterior fold to invaginate as extensively as the posterior fold. In contrast, constitutive activation of the small GTPase Rap1 restricts invagination of both dorsal folds in an α-Catenindependent manner. Rap1 activity appears spatially modulated by Rapgap1, whose expression levels are high in the cells that flank the posterior fold, but low in the anterior fold. We propose a model whereby distinct activity states of Rap1 modulate α-Catenin-dependent coupling between junctions and actin to control the extent of epithelial invagination
Publication Date: 13-May-2013
Electronic Publication Date: 25-Apr-2013
Citation: Wang, Yu-Chiun, Khan, Zia, Wieschaus, Eric F. (2013). Distinct Rap1 Activity States Control the Extent of Epithelial Invagination via α-Catenin. Developmental Cell, 25 (3), 299 - 309. doi:10.1016/j.devcel.2013.04.002
DOI: doi:10.1016/j.devcel.2013.04.002
ISSN: 1534-5807
Pages: 299 - 309
Type of Material: Journal Article
Journal/Proceeding Title: Developmental Cell
Version: Author's manuscript

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