Encapsulated Activated Grape Seed Extract: A Novel Formulation with Anti-Aging, Skin-Brightening, and Hydration Properties
Author(s): Tao, Kan; Guo, Lili; Hu, Xincheng; Fitzgerald, Corey; Rouzard, Karl; et al
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Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tao, Kan | - |
dc.contributor.author | Guo, Lili | - |
dc.contributor.author | Hu, Xincheng | - |
dc.contributor.author | Fitzgerald, Corey | - |
dc.contributor.author | Rouzard, Karl | - |
dc.contributor.author | Healy, Jason | - |
dc.contributor.author | Tamura, Masanori | - |
dc.contributor.author | Stock, Jeffry B | - |
dc.contributor.author | Stock, Maxwell | - |
dc.contributor.author | Pérez, Eduardo | - |
dc.contributor.author | Fernández, José R | - |
dc.date.accessioned | 2024-03-11T22:26:49Z | - |
dc.date.available | 2024-03-11T22:26:49Z | - |
dc.identifier.citation | Tao, Kan, Guo, Lili, Hu, Xincheng, Fitzgerald, Corey, Rouzard, Karl, Healy, Jason, Tamura, Masanori, Stock, Jeffry B, Stock, Maxwell, Pérez, Eduardo, Fernández, José R. (Encapsulated Activated Grape Seed Extract: A Novel Formulation with Anti-Aging, Skin-Brightening, and Hydration Properties. Cosmetics, 9 (1), 4 - 4. doi:10.3390/cosmetics9010004 | en_US |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr1ww77055 | - |
dc.description.abstract | Protein phosphatase 2A (PP2A) is a master regulatory protein that plays a critical role in oxidative stress signaling. A novel, proprietary grape seed extract called Activated Grape Seed Extract (AGSE), enriched for PP2A-activating flavonoids, was recently developed and demonstrated to have antioxidant and anti-inflammatory activities. AGSE is a purple-colored powder, with limited solubility restricting its use in a broad range of formulations. Our aim was to develop a formulation that reduced the color and increased the solubility of AGSE, allowing its skin-health-enhancing properties to be utilized in a wider array of products, and to test it clinically. Encapsulation was performed utilizing a liposome and hydroxypropyl-β-cyclodextrin, (HPCD)-based approach to produce Encapsulated AGSE (E-AGSE). Human dermal fibroblasts and epidermal keratinocytes were used to determine expression levels of aging and dermal–epidermal junction (DEJ) markers. EpiDerm™ was UVB-irradiated to measure the effects against cytokine release, DNA damage, apoptosis, and skin barrier. Human melanocytes were used to determine melanin production and mushroom tyrosinase was used for inhibitory activity. A 4-week, 31-subject sensitive-skin clinical was performed with 2% E-AGSE Essence to assess its activity on human skin. We demonstrated that E-AGSE inhibits PP2A demethylation, increases key anti-aging (collagen I, III, elastin) and DEJ markers, protects against UVB-induced DNA damage, reduces inflammation, and promotes filaggrin in vitro. Moreover, E-AGSE reduces melanin production via tyrosinase inhibition. Clinical assessment of E-AGSE showed that it reduces the appearance of wrinkles, brightens the skin, and boosts hydration. E-AGSE is a novel grape seed extract formulation enriched for PP2A-activating flavonoids that is clinically effective in sensitive skin, providing several benefits. | en_US |
dc.language | en | en_US |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Cosmetics | en_US |
dc.rights | Final published version. This is an open access article. | en_US |
dc.title | Encapsulated Activated Grape Seed Extract: A Novel Formulation with Anti-Aging, Skin-Brightening, and Hydration Properties | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.3390/cosmetics9010004 | - |
dc.date.eissued | 2021-12-30 | en_US |
dc.identifier.eissn | 2079-9284 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
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cosmetics-09-00004-v2.pdf | 2.2 MB | Adobe PDF | View/Download |
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