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Regulation of cancer metastasis by cell-free miRNAs

Author(s): Alečković, Maša; Kang, Yibin

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dc.contributor.authorAlečković, Maša-
dc.contributor.authorKang, Yibin-
dc.identifier.citationAlečković, Maša, Kang, Yibin. (2015). Regulation of cancer metastasis by cell-free miRNAs. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1855 (1), 24 - 42. doi:10.1016/j.bbcan.2014.10.005en_US
dc.description.abstractMicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression.en_US
dc.format.extent24 - 42en_US
dc.relation.ispartofBiochimica et Biophysica Acta (BBA) - Reviews on Canceren_US
dc.rightsAuthor's manuscripten_US
dc.titleRegulation of cancer metastasis by cell-free miRNAsen_US
dc.typeJournal Articleen_US

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