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Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization

Author(s): Wilson, Maxwell Z; Gitai, Zemer

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Abstract: Recent studies have identified a growing number of mesoscale protein assemblies in both bacterial and eukaryotic cells. Traditionally, these polymeric assemblies are thought to provide structural support for the cell and thus have been classified as the cytoskeleton. However a new class of macromolecular structure is emerging as an organizer of cellular processes that occur on scales hundreds of times larger than a single protein. We propose two types of self-assembling structures, dynamic globules and crystalline scaffolds, and suggest they provide a means to achieve cell-scale order. We discuss general mechanisms for assembly and regulation. Finally, we discuss assemblies that are found to organize metabolism and what possible mechanisms may serve these metabolic enzyme complexes.
Publication Date: Apr-2013
Citation: Wilson, Maxwell Z, Gitai, Zemer. (2013). Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization. Current Opinion in Microbiology, 16 (2), 177 - 183. doi:10.1016/j.mib.2013.03.008
DOI: doi:10.1016/j.mib.2013.03.008
ISSN: 1369-5274
Pages: 177 - 183
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Microbiology
Version: Author's manuscript

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