Skip to main content

A Common Set of DNA Regulatory Elements Shapes Drosophila Appendages

Author(s): McKay, Daniel J; Lieb, Jason D

To refer to this page use:
Abstract: Animals have body parts made of similar cell types located at different axial positions (e.g. limbs). The identity and distinct morphology of each structure is often specified by the activity of different “master regulator” transcription factors. Although similarities in gene expression have been observed between body parts made of similar cell types, it is not known how regulatory information in the genome is differentially utilized to create morphologically diverse structures in development. Here, we use genome-wide open chromatin profiling to show that among the Drosophila appendages, the same DNA regulatory modules are accessible throughout the genome at a given stage of development, except at the loci encoding the master regulators themselves. In addition, while open chromatin profiles change over developmental time, these changes are coordinated between different appendages. We propose that master regulators create morphologically distinct structures by differentially influencing the function of the same set of DNA regulatory modules.
Publication Date: 11-Nov-2013
Citation: McKay, Daniel J, Lieb, Jason D. (2013). A Common Set of DNA Regulatory Elements Shapes Drosophila Appendages. Developmental Cell, 27 (3), 306 - 318. doi:10.1016/j.devcel.2013.10.009
DOI: doi:10.1016/j.devcel.2013.10.009
ISSN: 1534-5807
Pages: 306 - 318
Type of Material: Journal Article
Journal/Proceeding Title: Developmental Cell
Version: Author's manuscript
Notes: Author listed as located at Princeton.

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.