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Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

Author(s): Pelliccia, Jose L.; Jindal, Granton A.; Burdine, Rebecca D.

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dc.contributor.authorPelliccia, Jose L.-
dc.contributor.authorJindal, Granton A.-
dc.contributor.authorBurdine, Rebecca D.-
dc.date.accessioned2020-02-24T18:50:23Z-
dc.date.available2020-02-24T18:50:23Z-
dc.date.issued2017-11-15en_US
dc.identifier.citationPelliccia, Jose L, Jindal, Granton A, Burdine, Rebecca D. (2017). Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. eLife, 6, doi:10.7554/eLife.28635en_US
dc.identifier.issn2050-084X-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1v19f-
dc.description.abstractVertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has not been fully explored. We show that zygotic expression of gdf3 is dispensable for embryonic development, while maternally deposited gdf3 is required for mesendoderm formation and dorsal-ventral patterning. We further show that Gdf3 can affect left-right patterning at multiple stages, including proper development of regional cell morphology in Kupffer's vesicle and the establishment of southpaw expression in the lateral plate mesoderm. Collectively, our data indicate that gdf3 is critical for robust Nodal signaling at multiple stages in zebrafish embryonic development.en_US
dc.format.extent1 - 23en_US
dc.languageengen_US
dc.language.isoen_USen_US
dc.relation.ispartofeLifeen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleGdf3 is required for robust Nodal signaling during germ layer formation and left-right patterningen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.7554/eLife.28635-
dc.identifier.eissn2050-084X-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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