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Stress, Stress Hormones, and Adult Neurogenesis

Author(s): Schoenfeld, Timothy J.; Gould, Elizabeth

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Abstract: The dentate gyrus of the hippocampus continues to produce new neurons throughout adulthood. Adult neurogenesis has been linked to hippocampal function, including learning and memory, anxiety regulation and feedback of the stress response. It is thus not surprising that stress, which affects hippocampal function, also alters the production and survival of new neurons. Glucocorticoids, along with other neurochemicals, have been implicated in stress-induced impairment of adult neurogenesis. Paradoxically, increases in corticosterone levels are sometimes associated with enhanced adult neurogenesis in the dentate gyrus. In these circumstances, the factors that buffer against the suppressive influence of elevated glucocorticoids remain unknown – their discovery may provide clues to reversing pathological processes arising from chronic exposure to aversive stress.
Publication Date: Jan-2012
Electronic Publication Date: 31-Jan-2011
Citation: Schoenfeld, Timothy J, Gould, Elizabeth. (2012). Stress, stress hormones, and adult neurogenesis. Experimental Neurology, 233 (1), 12 - 21. doi:10.1016/j.expneurol.2011.01.008
DOI: doi:10.1016/j.expneurol.2011.01.008
ISSN: 0014-4886
Pages: 12 - 21
Type of Material: Journal Article
Journal/Proceeding Title: Experimental Neurology
Version: Author's manuscript

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