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Hepatocarcinogenesis associated with hepatitis B, delta and C viruses

Author(s): Shirvani-Dastgerdi, Elham; Schwartz, Robert E; Ploss, Alexander

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Abstract: Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.
Publication Date: Oct-2016
Electronic Publication Date: 6-Aug-2016
Citation: Shirvani-Dastgerdi, Elham, Schwartz, Robert E, Ploss, Alexander. (2016). Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Current Opinion in Virology, 20 (1 - 10. doi:10.1016/j.coviro.2016.07.009
DOI: doi:10.1016/j.coviro.2016.07.009
ISSN: 1879-6257
Pages: 1 - 10
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Virology
Version: Author's manuscript

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