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DYT1 dystonia increases risk taking in humans

Author(s): Arkadir, David; Radulescu, Angela; Raymond, Deborah; Lubarr, Naomi; Bressman, Susan B.; et al

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Abstract: It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.
Publication Date: 1-Jun-2016
Electronic Publication Date: 1-Jun-2016
Citation: Arkadir, David, Radulescu, Angela, Raymond, Deborah, Lubarr, Naomi, Bressman, Susan B, Mazzoni, Pietro, Niv, Yael. (2016). DYT1 dystonia increases risk taking in humans. eLife, 5 (10.7554/eLife.14155
DOI: doi:10.7554/eLife.14155
EISSN: 2050-084X
Pages: 1-13
Type of Material: Journal Article
Journal/Proceeding Title: eLife
Version: Final published version. This is an open access article.

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