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Proteomics of nucleocytoplasmic partitioning

Author(s): Nguyen, Thao; Pappireddi, Nishant; Wühr, Martin

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Abstract: The partitioning of the proteome between nucleus and cytoplasm affects nearly every aspect of eukaryotic biology. Despite this central role, we still have a poor understanding of which proteins localize in the nucleus and how this varies in different cell types and conditions. Recent advances in quantitative proteomics and high-throughput imaging are starting to close this knowledge gap. Studies on protein interaction are beginning to reveal the spectrum of cargos of nuclear import and export receptors. We anticipate that it will soon be possible to predict each protein's nucleocytoplasmic localization based on its importin/exportin interactions and its estimated diffusion rate through the nuclear pore. This insight is likely to provide us with a fundamental understanding of how cells use nucleocytoplasmic partitioning to encode and relay information.
Publication Date: Feb-2019
Citation: Nguyen, Thao, Pappireddi, Nishant, Wühr, Martin. (2019). Proteomics of nucleocytoplasmic partitioning. Current opinion in chemical biology, 48 (55 - 63). doi:10.1016/j.cbpa.2018.10.027
DOI: doi:10.1016/j.cbpa.2018.10.027
ISSN: 1367-5931
EISSN: 1879-0402
Pages: 55 - 63
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Chemical Biology
Version: Author's manuscript

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