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Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe.

Author(s): Douam, Florian; Ploss, Alexander

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Abstract: Yellow fever (YF) was one of the most dangerous infectious diseases of the 18th and 19th centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is yellow fever virus (YFV) and its live-attenuated form, YFV-17D, remains one of the most potent vaccines ever developed. During the first half of the 20th century, vaccination combined with mosquito control eradicated YFV transmission in urban areas. However, the recent 2016–2018 outbreaks in areas with historically low or no YFV activity have raised serious concerns for an estimated 400– 500 million unvaccinated people who now live in at-risk areas. Once a forgotten disease, we highlight here that YF still represents a very real threat to human health and economies. As many gaps remain in our understanding of how YFV interacts with the human host and causes disease, there is an urgent need to address these knowledge gaps and propel YFV research forward.
Publication Date: 26-Nov-2018
Electronic Publication Date: 19-Jun-2018
Citation: Douam, Florian, Ploss, Alexander. (2018). Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe.. Trends in microbiology, 26 (11), 913 - 928. doi:10.1016/j.tim.2018.05.012
DOI: doi:10.1016/j.tim.2018.05.012
ISSN: 0966-842X
EISSN: 1878-4380
Pages: 913 - 928
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Trends in microbiology
Version: Author's manuscript

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