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A Test of the Coordinated Expression Hypothesis for the Origin and Maintenance of the GAL Cluster in Yeast

Author(s): Lang, Gregory I; Botstein, David

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dc.contributor.authorLang, Gregory I-
dc.contributor.authorBotstein, David-
dc.date.accessioned2020-02-25T20:11:26Z-
dc.date.available2020-02-25T20:11:26Z-
dc.date.issued2011-09-22en_US
dc.identifier.citationLang, Gregory I, Botstein, David. (2011). A Test of the Coordinated Expression Hypothesis for the Origin and Maintenance of the GAL Cluster in Yeast. PLoS ONE, 6 (9), e25290 - e25290. doi:10.1371/journal.pone.0025290en_US
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1rf59-
dc.description.abstractMetabolic gene clusters—functionally related and physically clustered genes—are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters.en_US
dc.format.extent1 - 7en_US
dc.language.isoenen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleA Test of the Coordinated Expression Hypothesis for the Origin and Maintenance of the GAL Cluster in Yeasten_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1371/journal.pone.0025290-
dc.date.eissued2011-09-22en_US
dc.identifier.eissn1932-6203-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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