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Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.

Author(s): Mirzaei, Mehdi; Gupta, Veer B; Chick, Joel M; Greco, Todd M; Wu, Yunqi; et al

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dc.contributor.authorMirzaei, Mehdi-
dc.contributor.authorGupta, Veer B-
dc.contributor.authorChick, Joel M-
dc.contributor.authorGreco, Todd M-
dc.contributor.authorWu, Yunqi-
dc.contributor.authorChitranshi, Nitin-
dc.contributor.authorWall, Roshana Vander-
dc.contributor.authorHone, Eugene-
dc.contributor.authorDeng, Liting-
dc.contributor.authorDheer, Yogita-
dc.contributor.authorAbbasi, Mojdeh-
dc.contributor.authorRezaeian, Mahdie-
dc.contributor.authorBraidy, Nady-
dc.contributor.authorYou, Yuyi-
dc.contributor.authorSalekdeh, Ghasem Hosseini-
dc.contributor.authorHaynes, Paul A-
dc.contributor.authorMolloy, Mark P-
dc.contributor.authorMartins, Ralph-
dc.contributor.authorCristea, Ileana M-
dc.contributor.authorGygi, Steven P-
dc.contributor.authorGraham, Stuart L-
dc.contributor.authorGupta, Vivek K-
dc.identifier.citationMirzaei, Mehdi, Gupta, Veer B, Chick, Joel M, Greco, Todd M, Wu, Yunqi, Chitranshi, Nitin, Wall, Roshana Vander, Hone, Eugene, Deng, Liting, Dheer, Yogita, Abbasi, Mojdeh, Rezaeian, Mahdie, Braidy, Nady, You, Yuyi, Salekdeh, Ghasem Hosseini, Haynes, Paul A, Molloy, Mark P, Martins, Ralph, Cristea, Ileana M, Gygi, Steven P, Graham, Stuart L, Gupta, Vivek K. (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.. Scientific reports, 7 (1), 12685 - ?. doi:10.1038/s41598-017-12858-7en_US
dc.description.abstractABSTARCT:Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other neurodegenerative disorders by investigating glaucoma-associated protein changes in the retina and vitreous humour. The multiplexed Tandem Mass Tag based proteomics (TMT-MS3) was carried out on retinal tissue and vitreous humour fluid collected from glaucoma patients and age-matched controls followed by functional pathway and protein network interaction analysis. About 5000 proteins were quantified from retinal tissue and vitreous fluid of glaucoma and control eyes. Of the differentially regulated proteins, 122 were found linked with pathophysiology of Alzheimer's disease (AD). Pathway analyses of differentially regulated proteins indicate defects in mitochondrial oxidative phosphorylation machinery. The classical complement pathway associated proteins were activated in the glaucoma samples suggesting an innate inflammatory response. The majority of common differentially regulated proteins in both tissues were members of functional protein networks associated brain changes in AD and other chronic degenerative conditions. Identification of previously reported and novel pathways in glaucoma that overlap with other CNS neurodegenerative disorders promises to provide renewed understanding of the aetiology and pathogenesis of age related neurodegenerative diseases.en_US
dc.format.extent1 - 16en_US
dc.relation.ispartofScientific reportsen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleAge-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.en_US
dc.typeJournal Articleen_US

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