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Mitosis-associated repression in development

Author(s): Esposito, Emilia; Lim, Bomyi; Guessous, Ghita; Falahati, Hanieh; Levine, Michael

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Abstract: Transcriptional repression is a pervasive feature of animal development. Here, we employ live-imaging methods to visualize the Snail repressor, which establishes the boundary between the presumptive mesoderm and neurogenic ectoderm of early Drosophila embryos. Snail target enhancers were attached to an MS2 reporter gene, permitting detection of nascent transcripts in living embryos. The transgenes exhibit initially broad patterns of transcription but are refined by repression in the mesoderm following mitosis. These observations reveal a correlation between mitotic silencing and Snail repression. We propose that mitosis and other inherent discontinuities in transcription boost the activities of sequence-specific repressors, such as Snail.
Publication Date: Jul-2016
Citation: Esposito, Emilia, Lim, Bomyi, Guessous, Ghita, Falahati, Hanieh, Levine, Michael. (2016). Mitosis-associated repression in development. Genes & development, 30 (13), 1503 - 1508. doi:10.1101/gad.281188.116
DOI: doi:10.1101/gad.281188.116
ISSN: 0890-9369
EISSN: 1549-5477
Pages: 1503 - 1508
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Genes & Development
Version: Final published version. This is an open access article.

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