Broadly neutralizing antibodies abrogate established hepatitis C virus infection
Author(s): de Jong, YP; Dorner, M; Mommersteeg, MC; Xiao, JW; Balazs, AB; et al
DownloadTo refer to this page use:
http://arks.princeton.edu/ark:/88435/pr1pv6b683
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | de Jong, YP | - |
dc.contributor.author | Dorner, M | - |
dc.contributor.author | Mommersteeg, MC | - |
dc.contributor.author | Xiao, JW | - |
dc.contributor.author | Balazs, AB | - |
dc.contributor.author | Robbins, JB | - |
dc.contributor.author | Winer, BY | - |
dc.contributor.author | Gerges, S | - |
dc.contributor.author | Vega, K | - |
dc.contributor.author | Labitt, RN | - |
dc.contributor.author | Donovan, BM | - |
dc.contributor.author | Giang, E | - |
dc.contributor.author | Krishnan, A | - |
dc.contributor.author | Chiriboga, L | - |
dc.contributor.author | Charlton, MR | - |
dc.contributor.author | Burton, DR | - |
dc.contributor.author | Baltimore, D | - |
dc.contributor.author | Law, M | - |
dc.contributor.author | Rice, CM | - |
dc.contributor.author | Ploss, A | - |
dc.date.accessioned | 2023-12-11T17:50:11Z | - |
dc.date.available | 2023-12-11T17:50:11Z | - |
dc.date.issued | 2014-09-17 | en_US |
dc.identifier.citation | de Jong, YP, Dorner, M, Mommersteeg, MC, Xiao, JW, Balazs, AB, Robbins, JB, Winer, BY, Gerges, S, Vega, K, Labitt, RN, Donovan, BM, Giang, E, Krishnan, A, Chiriboga, L, Charlton, MR, Burton, DR, Baltimore, D, Law, M, Rice, CM, Ploss, A. (2014). Broadly neutralizing antibodies abrogate established hepatitis C virus infection. Science Translational Medicine, 6 (254), 254ra129 - 254ra129. doi:10.1126/scitranslmed.3009512 | en_US |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr1pv6b683 | - |
dc.description.abstract | Hepatitis C virus (HCV) establishes a chronic infection in the majority of exposed individuals and can cause cirrhosis and hepatocellular carcinoma. The role of antibodies directed against HCV in disease progression is poorly understood. Neutralizing antibodies (nAbs) can prevent HCV infection in vitro and in animal models. However, the effects of nAbs on an established HCV infection are unclear. Here, we demonstrate that three broadly nAbs, AR3A, AR3B and AR4A, delivered with adeno-associated viral (AAV) vectors can confer protection against viral challenge in humanized mice. Furthermore, we provide evidence that nAbs can abrogate an ongoing HCV infection in primary hepatocyte cultures and in a human liver chimeric mouse model. These results showcase a novel therapeutic approach to interfere with HCV infection exploiting a previously unappreciated need for HCV to continuously infect new hepatocytes in order to sustain chronicity. | en_US |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Science Translational Medicine | en_US |
dc.rights | Author's manuscript | en_US |
dc.title | Broadly neutralizing antibodies abrogate established hepatitis C virus infection | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.1126/scitranslmed.3009512 | - |
dc.date.eissued | 2014-09-17 | en_US |
dc.identifier.eissn | 1946-6242 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Broadly_neutralizing_antibodies_hepatitis_c_infection.pdf | 706.67 kB | Adobe PDF | View/Download |
Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.