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|Abstract:||Microbes face intense competition in the natural world, and so need to wisely allocate their resources to multiple functions, in particular to metabolism. Understanding competition among metabolic strategies that are subject to trade-offs is therefore crucial for deeper insight into the competition, cooperation, and community assembly of microorganisms. In this work, we evaluate competing metabolic strategies within an ecological context by considering not only how the environment influences cell growth, but also how microbes shape their chemical environment. Utilizing chemostat-based resource-competition models, we exhibit a set of intuitive and general procedures for assessing metabolic strategies. Using this framework, we are able to relate and unify multiple metabolic models, and to demonstrate how the fitness landscape of strategies becomes intrinsically dynamic due to species-environment feedback. Such dynamic fitness landscapes produce rich behaviors, and prove to be crucial for ecological and evolutionarily stable coexistence in all the models we examined.|
|Citation:||Li, Zhiyuan, Liu, Bo, Li, Sophia Hsin-Jung, King, Christopher G, Gitai, Zemer, Wingreen, Ned S. (2020). Modeling microbial metabolic trade-offs in a chemostat. PLoS computational biology, 16 (8), e1008156 - e1008156. doi:10.1371/journal.pcbi.1008156|
|Pages:||e1008156 - e1008156|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||PLoS Computational Biology|
|Version:||Final published version. This is an open access article.|
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