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Development of Potent Inhibitors of Pyocyanin Production in Pseudomonas aeruginosa

Author(s): Miller, Laura C; O’Loughlin, Colleen T; Zhang, Zinan; Siryaporn, Albert; Silpe, Justin E; et al

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Abstract: The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.
Publication Date: 12-Feb-2015
Citation: Miller, Laura C, O’Loughlin, Colleen T, Zhang, Zinan, Siryaporn, Albert, Silpe, Justin E, Bassler, Bonnie L, Semmelhack, Martin F. (2015). Development of Potent Inhibitors of Pyocyanin Production in Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 58 (3), 1298 - 1306. doi:10.1021/jm5015082
DOI: doi:10.1021/jm5015082
ISSN: 0022-2623
EISSN: 1520-4804
Pages: 1 - 30
Type of Material: Journal Article
Journal/Proceeding Title: Journal of Medicinal Chemistry
Version: Author's manuscript

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