To refer to this page use:
|Abstract:||The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.|
|Citation:||Miller, Laura C, O’Loughlin, Colleen T, Zhang, Zinan, Siryaporn, Albert, Silpe, Justin E, Bassler, Bonnie L, Semmelhack, Martin F. (2015). Development of Potent Inhibitors of Pyocyanin Production in Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 58 (3), 1298 - 1306. doi:10.1021/jm5015082|
|Pages:||1 - 30|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Journal of Medicinal Chemistry|
Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.