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The Impact of Hepatitis C Virus Entry on Viral Tropism

Author(s): Ding, Qiang; von Schaewen, Markus; Ploss, Alexander

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Abstract: Uptake of hepatitis C virus (HCV) into hepatocytes is an orchestrated process, involving numerous host factors, virion-associated lipoproteins and a growing number of cell-associated factors. Several of these factors likely contribute to the hepatotropism and limited host range of this virus. Discerning the minimal set of human-specific factors required for viral uptake into nonhuman cells has facilitated the development of small animal models with inheritable HCV susceptibility. This review summarizes current knowledge of host factors required for HCV entry, the molecular mechanisms underlying HCV entry into hepatocytes, and aspects of viral entry contributing to HCV host tropism.
Publication Date: Nov-2014
Electronic Publication Date: 12-Nov-2014
Citation: Ding, Qiang, von Schaewen, Markus, Ploss, Alexander. (2014). The Impact of Hepatitis C Virus Entry on Viral Tropism. Cell Host & Microbe, 16 (5), 562 - 568. doi:10.1016/j.chom.2014.10.009
DOI: doi:10.1016/j.chom.2014.10.009
ISSN: 1931-3128
Pages: 562 - 568
Type of Material: Journal Article
Journal/Proceeding Title: Cell Host & Microbe
Version: Author's manuscript

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