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Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes.

Author(s): Ali, Md Zulfikar; Huang, Kerwyn Casey; Wingreen, Ned; Mukhopadhyay, Ranjan

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Abstract: We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.
Publication Date: Jan-2019
Citation: Ali, Md Zulfikar, Huang, Kerwyn Casey, Wingreen, Ned S, Mukhopadhyay, Ranjan. (2019). Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes.. Physical review. E, 99 (1-1), 012401 - ?. doi:10.1103/physreve.99.012401
DOI: doi:10.1103/physreve.99.012401
ISSN: 2470-0045
EISSN: 2470-0053
Pages: 012401-1 - 012401-10
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Physical Review E
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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