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Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities

Author(s): Shen, Minhong; Kang, Yibin

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Abstract: Metastasis is the ultimate "survival of the fittest" test for cancer cells, as only a small fraction of disseminated tumor cells can overcome the numerous hurdles they encounter during the transition from the site of origin to a distinctly different distant organ in the face of immune and therapeutic attacks and various other stresses. During cancer progression, tumor cells develop a variety of mechanisms to cope with the stresses they encounter, and acquire the ability to form metastases. Restraining these stress-releasing pathways could serve as potentially effective strategies to prevent or reduce metastasis and improve the survival of cancer patients. Here, we provide an overview of the tumor-intrinsic, microenvironment- and treatment-induced stresses that tumor cells encounter in the metastatic cascade and the molecular pathways they develop to relieve these stresses. We also summarize the preclinical and clinical studies that evaluate the potential therapeutic benefit of targeting these stress-relieving pathways.
Publication Date: Dec-2020
Citation: Shen, Minhong, Kang, Yibin. (2020). Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. Genes & development, 34 (23-24), 1577 - 1598. doi:10.1101/gad.343251.120
DOI: doi:10.1101/gad.343251.120
ISSN: 0890-9369
EISSN: 1549-5477
Pages: 1577 - 1598
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Genes & Development
Version: Final published version. This is an open access article.

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