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Chemical Sensing by Nonequilibrium Cooperative Receptors

Author(s): Skoge, Monica; Naqvi, Sahin; Meir, Yigal; Wingreen, Ned

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Abstract: Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors.
Publication Date: Jun-2013
Electronic Publication Date: 11-Jun-2013
Citation: Skoge, Monica, Naqvi, Sahin, Meir, Yigal, Wingreen, Ned S. (2013). Chemical Sensing by Nonequilibrium Cooperative Receptors. Physical Review Letters, 110 (24), 10.1103/PhysRevLett.110.248102
DOI: doi:10.1103/PhysRevLett.110.248102
ISSN: 0031-9007
EISSN: 1079-7114
Type of Material: Journal Article
Journal/Proceeding Title: Physical Review Letters
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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