Skip to main content

Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression

Author(s): Crocker, Amanda; Guan, Xiao-Juan; Murphy, Coleen T.; Murthy, Mala

To refer to this page use:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCrocker, Amanda-
dc.contributor.authorGuan, Xiao-Juan-
dc.contributor.authorMurphy, Coleen T.-
dc.contributor.authorMurthy, Mala-
dc.description.abstractLearning and memory formation in Drosophila rely on a network of neurons in the mushroom bodies (MB). While numerous studies have delineated roles for individual cell types within this network in aspects of learning or memory, whether or not these cells can also be distinguished by the genes they express remains unresolved. In addition, the changes in gene expression that accompany long-term memory formation within the MBs have not yet been studied by neuron type. Here we address both issues by performing RNA sequencing on single cell types (harvested via patch pipets) within the MB. We discover that the expression of genes that encode cell surface receptors is sufficient to identify cell types, and that a subset of these genes, required for sensory transduction in peripheral sensory neurons, are not only expressed within individual neurons of the MB in the central brain, but are also critical for memory formation.en_US
dc.relation.ispartofCell Reportsen_US
dc.rightsAuthor's manuscripten_US
dc.titleCell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expressionen_US
dc.typeJournal Articleen_US

Files in This Item:
File Description SizeFormat 
cell type specific.pdf1.6 MBAdobe PDFView/Download

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.